If you want to block Annotations on youtube videos or the annoying clickable "End Screen Cards" you see towards the end of some videos on youtube. Just add the following lines to UBlock Origin "My filters" tab and click apply changes.
youtube.com##.video-annotations
youtube.com##.ytp-ce-element
ytp-ce-element = End Screen Cards the clickable overlay you see on some youtube videos. I see too many channels on youtube that use them the wrong way, they end up blocking part of the video content.