When my computer wakes, sound is often muffled and the volume is not the same as before it went to sleep despite the volume setting being the same.
 
Sometimes, fiddling with the control panel fixes this. Lowering the sample rate and then moving it back to 192khz will sometimes work. Sometimes doing similar with ASIO buffer size works as well. Sometimes it requires the drivers to be reinstalled but that is an annoying and tedious process and the same thing happens when my computer goes to sleep or shuts down.
 
Is there anything I can do? When it works properly it is a fantastic card but when it is not it is no better than the onboard sound.
 
Windows 10 Pro Build 18363.900
Logitech Z623 2.1 Speakers
EVGA Z97 FTW mobo

Thanks but that is not exactly troubleshooting, just temporary fixes that might occasionally work like the things I posted and then break again on sleep. Anything that requires a reboot without being an actual fix defeats the purpose of sleep and pretty much makes this card pointless.

The volume and fuzzy sound happen at the same time and are 'fixed' in the same way. When this problem is going on I can move the system volume to 100% and the volume doesn't really increase that much. I normally keep it at 35% and never touch the speaker volume. There is no popping or crackling just lower volume and and the sound is not clear. It is the same across multiple applications that play sound.

Make sure you have the latest version of Win10 using the Update Assistant..Click "Update now" and then "Run" in the popup dialog.
 
Right-click on the NU Audio software desktop shortcut..Then Properties..Then Compatibilty..Then "Run this program as an administrator"..You can also choose to run in compatibility mode for different versions of Windows, like Win7..You can also "Register this program for restart" in the new version of Win10..Then "Change settings for all users".

See if any of that matters..Just throwing some darts here.