So a month ago I started having this problem when listening to YouTube or flying my flight sim, the sound would randomly go really bad--staticy, the instruments in the music would sound out of tune with each other and generally just sounding like garbage. I found I could temp fix it by closing and re-opening the browser and the YouTube page, but when you are 2 hours into a flight, it isn't that simple. Sometimes while on long flights in my sim it would clear up and fix itself. It isn't like it happens 5 minutes into flight or 10 or 15 or an hour or two and happens for some set amount of time, it literally comes and goes at random times.

Everything is updated--GPU (566.36) and all software on computer. I update and install all software that needs it, clean up the drives, optimize the drives and restart before I play the sim just to ensure the computer is in best shape for gaming.

It isn't heat-related as when I monitor Precision X1 all temps are within limits.

This isn't the power cable buzz/EMI issue either, from what I can understand that would happen constantly. Also this isn't an EMI sound--it is some sort of processing failure at the GPU, I believe.
 
Any useful input is appreciated. I really don't understand why this is happening or what is causing it.

What kind of cable?
 
I use a Logitech G35 headset (USB connected) and that is the only audio out. If the cable to that failed, I would assume I would have this issue constantly.

I rolled GPU back drivers--that was unsuccessful.

I haven't rolled back audio driver. I will look into that--thanks!

I don't have Bluetooth set up on this.

All controllers are USB connected.

Thanks for the responses, tatude69!

Yeah, the Logitech G35 (IMO) is the best bang for the buck. They sound great (mic and speakers) for the price. My second one and trying to hold on to it as long as possible!

I believe it is the GPU, because unless things changed and I totally missed it, doesn't the GPU still handle the bulk of sound processing? Correct me if I am wrong.

I can try using the TV speakers. 

So if I get another headset (one with 1/8th" jack or whatever) I'm going full on with it. Not prepared to invest in that quite yet.

And yes, it being a random thing with zero known triggers, it is frustrating. I hope it is simple as well.