Not sure what the issue is, I have a  EVGA GeForce GTX 1080 Ti SC Black Edition GAMING, 11G-P4-6393-KR with a EK block on it, it was working good with a decent overclock ( +43 core / + 439 mem / 119 Power limit)  temps stay under 54c. Been playing witcher3 and will get a bsod constantly unless its stock or under clocked. this only started happening when playing the witcher but i loaded up bf1 and it crashed also. 
 
 
 
 
 
 
 
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Welcome to the Forum brett36w
Uninstall EVGA Precision XOC if Installed, Delete the Program Folders *Make Sure to delete the Profile Folder.
Uninstall the Graphics Drivers and run DDU in SAFE MODE.
Install the Driver you want to Run and install only the Graphics Driver and PhysX Driver and nothing else (For Now)
Install EVGA Precision XOC 6.1.11
 Install the Standalone Version restart your Computer then run EVGA Precision XOC to update the Firmware. Exit EVGA Precision XOC and TURN OFF YOUR COMPUTER unplug the power cord till all the Motherboard LED (Lights) are all Off. Plug back in the Power Cable turn on tour Computer and recheck your Temps.
 
54C seems a little High under a Custom Water Loop, what is your Room Temperature?
OC the GPU and Leaving the Memory at the Stock Settings. Also set your Motherboard back to the Default or Optimized Settings NO OC on the MB.

brett36w
Been playing witcher3 and will get a bsod constantly unless its stock or under clocked. this only started happening when playing the witcher but i loaded up bf1 and it crashed also

Sounds like the cpu/gpu/ram overclock is unstable.

After installing witches 3 these issues began. I would get random game crashes once in a while but never bsod/whatdog clock errors until I installed this game and the new drivers. I was running at 4.9 on cpu and full on oc on gpu. Until this started happening