It's always best to use a separate cable for each connection and to daisy chain should always be used only as a last resort.

OP has 4 cables, two are single 6+2, and two double 6+2. Best practice is to use 1 cable per PCIE power plug for the 30 series. So in the OPs case, the two single 6+2 cables, and one of the dual 6+2 cables with the extra 6+2 hanging to the side & unused.

Thank you for the responses.  I'd like the cleaner look of just two cables so will start with the daisy chain + 1.

EVGA_JacobF
Yes 2 on a daisy chain + 1 is fine.

No, you are incorrect and giving bad advice Jacob.

https://forums.evga.com/G...ables-m3164416-p3.aspx

Unless each port needs more than 210+ watts, it's usable option. If you can, I would go for 3 separate ones if possible but that does not mean 1  + 2 (daisy chain) won't work unless that daisy chained ports suck up 425+ - maybe kingpin with extreme cooling? not sure.
 
IMO, the point is it will still work with at least with 3090 according to its latest power draw limit on the XOC bios.
 
Should you use daisy chain while you can avoid it? I would not.
But if you have to live with it, yes it will work fine.