Ok, so I've done more research and have come to the conclusion that my inverse case sub-optimal for multiple AIOs due to radiator placement choices.  While my CPU AIO radiator is positioned correctly, the 2080 hybrid positions the radiator below the pump built into the card where air in the line would sit. In my case, I'm having no issues with cooling: the 15 month old card runs in a custom O/C setup with MSI Afterburner, never gets above 61c at full load, and is whisper quiet. 
 
Moving to a 3080 hybrid would mean putting the 240mm radiator at the bottom (not top) of the case due to its inverse nature.  I suppose I'd be rolling the dice as to whether this will cause a long-term issue with the GPU, same with my current setup.  I'm guessing that I'm not the only one with this kind of setup, though.
 
My research:
Gamer Nexus AIO positioning (CPU-focused): youtu.be/tU7D6y_QYcI
EVGA forum post with basically my PC case and issue: EVGA-Hybrid-radiator-location-m2819420.aspx
 
You may be wondering why I have an inverse case.  I've used them for over a decade and prefer them because my PC is on the right edge of the desk and an inverse case makes it easy to open the right panel to work on it without having to move the PC.
 
Just wanted to post a response in case someone sees this in the future.

tamerlee
Strongly recommend placing your radiator above your pump so that the air doesn't get trapped in the pump. As air infiltrates into the loop, it will get worse over time.
 
If you mount an AIO radiator on the side, make sure the inlet and outlet are on bottom, as you're doing with your CPU radiator.

Unfortunately, I'm not seeing a way to do that in my case.  As shown in the photo, the front of the case is the only place that a GPU radiator could get above the GPU pump, and that's being used for the CPU AIO.