Anyone still using this sound card with their PC and playing Diablo IV? When I try to play audio through my headset powered by the Nu Audio Pro, the audio cuts out. If I change the audio source to my external DAC which powers my speakers, no issues with sound. I don't seem to have any issues with audio on any other games. It's just Diablo IV where I cannot get sound working. Is this an issue with the audio drivers?

Unchecked both settings as requested and as soon as I load into the realm, I lose sound. If I tell the game to use the EVGA card, I can hear sound momentarily, and then it just goes silent. If I change the game settings to default, I again get sound for a moment and then I lose it again. I'm attempting to scan and repair my downloaded game files to see if there is an issue with the game, but it doesn't seem too plausible since a different audio output works. 

Good call on the sample rate.
 
Originally had the sample rate as 24 bit, 41000 Hz, which wasn't working. On my external DAC, I had 24 bit, 48000 Hz, which was working, but it still didn't work when I changed this on the Nu Audio Pro card. Since I had no luck, I just applied the Windows default, and low and behold, it works. 32bit, 48000Hz working! Honestly, don't recall changing the sampling rate, but I've had this card for a while now. Weird this was the only gaming giving me issues with sound. 
 
Thank you!