Your base template looks good for the most part. Here are a few suggestions to start with:
 
The Mushkin memory can handle command rate of 1T:
 
Command Rate ( 1t )
 
Secondly, I would configure the memory frequency manually so that you know for sure that your target memory frequency is correct:
 
Memory Speed ( 2:8 )
 
The way to figure out the memory frequency using the above setting is to multiple 8 x the base clock. With base clock 162, your target memory frequency is 1296 MHz. This will give you flexibility to increase the base clock further to reach your goal of 4.6 - 4.8 GHz since your processor is multiplier locked.
 
Third, manually set the QPI frequency.
 
QPI Frequency Selection ( 4.8 GT/s )
 
You want to make sure that the target QPI frequency is as low as can be as QPI frequency increases with base clock. 4.8 GT/s is equivalent to 18x. 18x162= 2916 MHz. With most processors, 4000 MHz tends to be the wall for QPI frequency and some hit a wall lower than that frequency. You may also want to set your Uncore frequency manually to 1.5 - 2.0x the memory frequency. I would set as low as possible initially to minimize possibility of issues in this area.
 
Since your goal is to reach fairly high frequencies for this processor, I would suggest increasing the PWM frequencies for clean power delivery:
 
**VTT PWM Frequency ( 610 KHZ )
**CPU PWM Frequency ( 1200 KHZ )
 
Next I would set your CPU multiplier to 19x temporarily. This way you can test out stability for your base clock which will need to be at 184 to reach 4.6 GHz with the 25x multiplier. Turn up the base clock to 184 and retest stability. If you run into a wall with base clock, try setting QPI Signal Compensation to Less and adjust QPI PLL to 1.2v. You might need to adjust VTT. The VTT voltage is tied to the CPU Uncore. However, since your memory frequency is not that high, you probably will not need very high VTT. A possible range for VTT may be 1.2 - 1.25v for stability at your target Uncore frequency.
 
If all is well, gradually work up your multiplier again and adjust VCore as necessary. Keep in mind that depending on the CPU, you may need fairly high VCore to reach 4.6 GHz. You can also experiment with CPU Impedance. Set to Less if you run into a wall with reaching higher frequencies.