Nope. M2 & M3 are Gen 3.
Only M1 is Gen 4.
see page 19 of manual:
13. M.2 Socket 3 Key-M 110mm
(PM1)M.2 is an SSD form factor standard, which uses up to four PCIe lanes and
utilizes
up to Gen4 speeds, depending upon the device used. Most popularly
paired with NVMe SSDs, this standard offers substantially faster transfer speeds
and seek time than SATA interface standards. All M.2 devices are designed to
connect via a card-bus style connector, secured by bolting into place, and
powered by the connector – rather than a dedicated data cable and power cable.
This slot support device lengths of 110mm, 80mm, 60mm, and 42mm.
14. M.2 Socket 3 Key-M 110mm
(PM2)(PM3)M.2 is an SSD form factor standard, which uses up to four PCIe lanes and
utilizes
up to Gen3 speeds. Most popularly paired with NVMe SSDs, this
standard offers substantially faster transfer speeds and seek time than SATA
interface standards. All M.2 devices are designed to connect via a card-bus style
connector, secured by bolting into place, and powered by the connector – rather
than a dedicated data cable and power cable.
These slots support device lengths of 110mm, 80mm, 60mm, and 42mm.
and on page 20:
The 20 RKL Gen4 PCIe lanes are pulled from the CPU and shared with the x16
PCIe slot 2 (PE2) and M.2 Key-M 110mm (PM1)