EyeDeeNo
Just thinking about the changing of the digital vibrance, do you guys calibrate yourself to or apply the ICC profile for your monitors? Because changing of the digital vibrance would throw everything out the window if you do.
There are only a couple things I do mess with. Such as the games that use MSAA I apply Multi-Frame Sample AA to them. Of course I use NVIDIA's color settings for both DisplayPort and HDMI to get Full dynamic range also for the TV I set it to 12 bit color depth. Addition to that with the last update set Max Frame Rate under Global Settings. Dot Dot Period
If you are wanting color accuracy and calibrate with a tool (such as Spyder or any of the other ones) then you are not going to want to touch the digital vibrance setting. However, I do calibrate my monitor (create different profiles) for different gamma levels. I have 1.6, 1.8, 2.0 and 2.2 color profiles. This way I can change it to preference in certain games. When I play FPS games I usually use the 2.0 profile or less.
As for changing Nvidia settings, it depends on what you are looking for. I do use the ultra low latency mode because it lowers input lag, which I prefer. I also get rid of Gysnc for the same reason, to lower input lag. I have been experimenting with image sharpening... I don't believe that you should never really change settings in the Nvidia control panel, but you should know what you are doing.