You will have to do your homework, if you want to water cool with a semi-custom or custom loop.
 
(Below are some useful links, they are in no particular order)
 
What case gives you the room you'll need, size of Radiator(s) that fit, how to test, how to maintain the loop.
 
For your reading pleasure: help you understand your options & limits


                                       


 
LINK1
http://www.overclock.net/t/226970/updated-water-cooling-essential-threads
 
LINK2
http://www.xtremerigs.net/2014/01/20/first-watercooling-loop/
 
LINK3-A
http://www.overclockers.c...s-guide-water-cooling/
 
LINK3-B
http://www.overclock.net/t/766479/watercooling-guide-for-beginner
 
LINK4
http://www.overclock.net/...my-pump-handle-a-guide
 
LINK5
http://www.xtremerigs.net/2015/02/11/radiator-round-2015/5/
 
LINK6
http://www.xtremerigs.net...er-cooling/pumps-tops/
 
LINK7-A
http://www.tomshardware.com/reviews/a-beginners-guide-for-watercooling-your-pc,1573.html
 
LINK7-B
http://www.tomshardware.com/forum/277130-29-read-first-watercooling-sticky
 
LINK8-A
http://www.overclockers.com/pc-water-coolant-chemistry-part-i/
 
LINK8-B
http://www.overclockers.com/pc-water-coolant-chemistry-part-ii/
 
LINK9
http://forums.extremeoverclocking.com/showthread.php?t=354844
 
LINK10
http://www.overclock.net/t/1500007/best-way-to-clean-radiators
 
LINK11
http://www.overclock.net/t/1534282/how-to-correctly-leak-test-your-loop-101
 
LINK12
http://thermalbench.com/category/fans/
 
LINK13
https://www.ekwb.com/guides/
 
LINK14
https://www.ekwb.com/solutions/
 
Guides:
 
gamersnexus -  Hard Tube Bending Tutorial for Open Loop Liquid Cooling
 
primochill -  Choosing the right Tubing
----------------------------------------------------------------------------------------
  To "do the Math to compute heat loads" TDP & Calculating Delta-T
 
(excerpts)

First tip: Google is your best friend to help find TDP (Thermal Design Power) of your components to be cooled in your loop.

(CPU watts @load + GPU watts @load + GPU watts @load+ pump watts) x 0.85 = Loop TDP watt estimate
 
To help calculate a full system TDP, you can download the interactive TDP and radiator estimation sheet (link) I* put together to help you. 
(I*= the Author - from the link)
 -------------------------------------------------------------------------------------
 
edits:
1) update list 8/19/2017
2) Added Guides 01/29/2020
 
3) kougar (post 60)  https://www.reddit.com/r/watercooling/ is pretty good too, active subreddit with a very active discord channel.
 
4) put manual calculation info on front page (post 35)
 
5) added tags to make this thread easier to find

I think this belongs here too. This topic is about bending your hard pipes. Makes it look nice, but takes loads thinking and doing. Might not be the best choice for starters (but who am i to deny? Go for it.). Also, i used paper to calculate my circulation; which fittings and where. Good luck all who is about to do some watercooling, its really nice 
 
http://www.overclock.net/...crylic-pipebending-101

GTX, very cool thread you made. Definitely a place, like me, to come and look up information on watercooling.
 
Your title, though, reminds me of this (lol) :
 

stalinx20
GTX, very cool thread you made. Definitely a place, like me, to come and look up information on watercooling.
 
Your title, though, reminds me of this (lol) :
 

Agree
 
Title edit complete

Mods should make this a sticky.

This is great. I spent a very large amount of time bringing my dual 980 hydrocopper rig online. 2 radiators, and 6 fans keeps the cpu and ambient water temps at a steady 45c to 48c 

stalinx20
Mods should make this a sticky.

+1

Thank you, this is great and very helpful, I will be linking this to my buddies.

Glad you found it helpful

Jbj5000
Thank you, this is great and very helpful, I will be linking this to my buddies.