Intermittent issues are always the hardest ones to resolve
Could be a bad solder joint, some sort of bad: contact or chip or other issue that needs the perfect storm to make the issue happen
Might be some sort of electrical noise issue?
What is the power source you are using? plugged direct into wall outlet/ surge protector or UPS?
Any other larger devises in your house/ apartment on the same circuit as the PC? (microwave, refrigerator, a/c unit)
RE: 750W PSU --> That GPU spec is for 850 Watt or greater power supply.
Browser?
Other software that is typically running in the background?
You are using the Nvidia sound driver & not the MB's sound chip?
HDMI or DP?
Tried other cables or all other ports on GPU?
Which Nvidia drivers have you tried?
Ever use DDU to remove all previous GPU drivers before installing a new driver?
It might be some sort of driver conflict. One easy test - disabling MB sound in BIOS