Unlikely, since the cards do not have a higher power limit compared to air-cooled or HYBRID cards. The HC cards also use a slightly different layout with SP caps near the memory chips for better waterblock mounting, which none of the other cards have. Using the HC BIOS, then, could have some negative effects on non-HC cards due to different components. On the other hand, if you have an HC card and want to try a different BIOS, I've been told that there shouldn't be any issues with the non-HC BIOS options; however, that's not a definite 100%.