I have numerous issues loosing the software, always after windows update or a BSOD, I finally found how to get it sorted:
Uninstall the software, Reboot, delete all evga folders, got to %appdata% theres a hidden file there and delete it, reboot, re-install all is good.  Works everytime for me, I know its a pain but it keeps this quality card and software working

I've had that happen to me a couple of times, and all I've had to do was delete the EVGA folder in the path specified in the following post and I was good to go: https://forums.evga.com/FindPost/3253885
No uninstalling and reinstalling required.
 
I have to say this audio card was well worth taking the chance on buying it on eBay from Audio Note. It's awesome.