To "do the Math to compute heat loads"
TDP & Calculating Delta-T (excerpts)
First tip: Google is your best friend to help find TDP (Thermal Design Power) of your components to be cooled in your loop.
(CPU watts @load + GPU watts @load + GPU watts @load+ pump watts) x 0.85 = Loop TDP watt estimate
To help calculate a full system TDP, you can download the interactive
TDP and radiator estimation sheet (link) I* put together to help you.
(I*= the Author - from the link)