Do you have System Restore turned on? It might be as easy as restoring an earlier point to fix whatever Windows update borked things up.
 
http://home.bt.com/tech-gadgets/computing/how-to-fix-windows-10-problems-with-system-restore-11364008291943 
 
That same guide has instructions on how to refresh the OS and keep your files intact as well, should you not have system restore turned on or if it fails.
 
 
 
You can also open up the command prompt and run "sfc /scannow" to have windows scan for and fix any corrupted windows files: https://support.microsoft.com/en-us/kb/929833 
 
You can also burn a memtest86 (free!) disc to check to see if your RAM has a problem (it boots from the disc like a Windows install disc): http://www.memtest86.com/  - let it run for a while, several complete passes, to verify the RAM is OK.

arestavo
Do you have System Restore turned on? It might be as easy as restoring an earlier point to fix whatever Windows update borked things up.
 
http://home.bt.com/tech-gadgets/computing/how-to-fix-windows-10-problems-with-system-restore-11364008291943 
 
That same guide has instructions on how to refresh the OS and keep your files intact as well, should you not have system restore turned on or if it fails.
 
 
 
You can also open up the command prompt and run "sfc /scannow" to have windows scan for and fix any corrupted windows files: https://support.microsoft.com/en-us/kb/929833 
 
You can also burn a memtest86 (free!) disc to check to see if your RAM has a problem (it boots from the disc like a Windows install disc): http://www.memtest86.com/  - let it run for a while, several complete passes, to verify the RAM is OK.

I'm not sure if I have system restore on or not.  I have my own backup solution, I run Acronis every Tuesday, and create a full image, that I store on a 4T internal drive in this system.  I will try that link, as I have backups I can always fall back upon.  If that works, great.  If not, then I think I will do a fresh format and start from scratch (or rather just wait to get my hands on the new M.2 Samsung drive and just unplug my SSDs for the time being).
 
Thanks for the tips.  I will report back my findings.

It could be your soundcard if the same output is making that type of noise.  Make sure all your settings are set right in the software and search to see if others have had this issue.

Cool GTX
Any issues in Device Manager ?
 
If you have a sound card and its driver loaded, did you also load the Nvidia GPU driver including Nvidia sound drivers ? 
 
You can do a custom install of Nvidia driver and Not select the sound drivers from Nvidia. - unless you like to use HDMI or DP with sound  from monitor sperakers

That might be it, I did the nVidia drivers and didn't do custom.  Doh!!

Ok, that wasn't it with the sound.  Still having that issue.
 
 
BUT.....I woke up this morning, booted into Windows super fast, start checking email, them BAM, it locks up again.  Can't move anything, no control + alt + delete, nothing.  I hit the reset button on the case (which earlier on in this problem did work but then didn't) and nothing happened.  I wait about 20 seconds, and the system just reboots itself.
 
Yesterday I did get a couple blue screens, something about a page fault in nonpaged area.
 
So not sure what's causing this now.  Starting to wondering if I have a hardware issue that occurs if I let the computer sit for a period of time, that requires a reboot when I first turn it on, and then it goes away.
 
 
A side note, my left channel speaker is working this morning. (knocks on wood)  Makes no sense there.  Everything is good in device manager.

I'm running the new Samsung 960 Pro M.2 512G as my boot drive, and then I have a 500g mechanical for storage, as well as a 4T for more storage.
 
 
So I tried yesterday, and I'm able to replicate the problem, by shutting the switch off on the power supply, pressing the button, and then waiting for maybe a minute, power back on, and it will lock up about 30 seconds after on the desktop.

Everything is at stock clocks. No overclocking what so ever.
 
I will try disconnecting all, when I get home from work.  Thanks.

Well I just got home, and before turning anything on, I removed the sata cable from my dvd burner, sata from my 500g drive, sata from my 4T drive, and removed the sound card from the PE4 slot.  Booted, and all was fine.  Will start adding sata cables, and see where that goes.  I got a feeling it's the sound card, as I've had them go bad before, and they do really goofy things when they do.  Will report back my findings.
 
Also, with the other drives removed, as the machine posted, it seemed to take a while to do so.  Not the normal set of beeps, just was missing one, and it took maybe 10 seconds before the last beep beeped.  Like a set of 3 beeps, then another set of 3 beeps, 10 second pause, 1 been.  That normal?  Maybe cause I removed the other hard drives, it was looking for but now aren't there, caused that?

Thanks for sharing this info with us which helps immensely.  It looks like to me that the board is the issue here.  Highly doubt all your peripherals that you've tested were the problem.  I would even go as far as testing all those on another rig to be 100% sure but I highly doubt it will make a difference really.  I think its time you go through RMAing the MB.  Obviously something is wrong with the board OR by chance it doesn't have the right or conflicting drivers to it.  Make sure everything was update via EVGA download center.  If all is well there, than continue to go down the RMA path.

I mean you don't have to but just to start fresh and if it isn't too much of a hassle, I would.
 
Glad to hear you got the RMA in process and hope to hear great news once its all said and done.

So it's been a while since I've posted, thought I'd send an update about this.  
 
I did get a new board, second one that was tested longer to make sure things were good.  I put my M.2 drive in, and the board wouldn't boot.  Long story short the M.2 drive was the cause.  I tested it by putting it in my brand new Z270 system (thank goodness I bought that, or I'd be without a computer for almost 4 months!!!) and it wouldn't boot.  So I have to get a hold of Samsung cause I'm 5 days past being able to return it to Newegg.  WOW, are they slow!  I contacted them and was sent an email form to fill out, they said it'd be 1-2 days.  A week later, I had to send another email asking for someone to look into where my RMA was at, and 2 days after that they finally send me info where to send it.  I send it out, and they were slow to even look at it, and after their 10 period they said they'd have it resolved......was closer to 2 weeks, I email for a status update.  They said it couldn't be repaired and were going to send me a new one.  10 days after that I get an email that they are out of stock and no ETA on when they are to be back in stock.  More time later they finally say they are going to issue me a refund.  A week after that, I ask about the status and am told 14-21 days for a refund.  I just got me refund check yesterday.  I found one on Amazon and had it here right after they said there were none in stock..... and had to pay tax and it cost me $20 more...dammit!
 
 
SO, not really wanting to do anything with it, I let it sit for a few weeks.  I finally threw in the M.2 drive, and start installing windows.  Everything goes normal, I'm in windows configuring everything to my liking, when it locks up.  I had to push the power switch to reboot it and it's fine after that.  I make some more changes  (auto login stuff) and I get curious. I shut down the rig, flip the switch on the power supply, and push the on button to make sure things are drained.  I turn the power switch back on, start up the rig.  I get to the desktop, move the mouse around, 10 seconds later, it locks up again!!!   The SAME EXACT PROBLEM I had before!!!   I have changed out everything but the GTX590.  It's a new motherboard, cpu, ram, power supply, M.2 drive.  I don't think my CD drive is even hooked up.
 
Needless to say I'm not really happy right now.  Could a vid card cause this issue?  I don't have a newer one to try.  I refuse to pull anything out of my Z270 rig to test with.  I don't need 2 rigs down.  I'll be calling EVGA tomorrow night again it seems!
 
Maybe I should just part the whole thing out and get rid of it!

Are you running the latest motherboard bios?

I haven't tried safe mode..........working on that now.
 
Yes, Bios is latest.  Got all drivers right from EVGA's site, as it's EVGA x99 board and EVGA GTX590.  After MB drivers were installed, I did a windows update (win10 pro).  Still locks up.
 
Will report back on the safe mode.