Well so far Core 22 is going well, no errors at all (knock on wood) for my rigs.  Nice thing is I have picked up over 2M PPD.  I would of had to built another computer and put a 2080TI in it to get to that stage.  What really has me excited is they stated there will be a CUDA version of the core coming out in future releases.   That could give us even better performance on the NVIDIA GPU's.
 
What is even more interesting is Bruce and I over at the Stanford folding forums had a back and forth about a new core should come to work better with the newer GPU's.  He said it would never matter since the core cannot run better on newer hardware.  Well in what I have been reading old tech cards are really not seeing a gain on Core 22 Beta but the newer Pascal and Turing cards are seeing nice gains.  To me that says the core is designed to take more advantage of maximizing the use of the newer GPUs.  Well that just my morning ramble, carry on!!!

Let's just leave it at Bruce has no idea how the increase in code efficiency in combination with the new hardware designs mesh together. Either that, or he's a die-hard AMD folder that's not had the same generational benefit increases the way Nvidia folders have.
 
d

why release a new core for no gain or benefit?

@ipka, the way to fold is actually to cut power to your GPUs.
Most of my GPUs run at ~55-60% of their max TDP (190W (2060s), run at 125W, 225W cards run at 127W, 250W cards run at 140W, and the 2080Tis run at ~180W), and all of them are running at 1900+Mhz, with an occasional 2010Mhz for the 2060 Rog Strix.
The difference between 1900Mhz and 2010Mhz is less than 5-10% of PPD; but the power savings are 40-50% of total system power!
That energy savings can be best put in another GPU, that will make well more than 10% of performance loss!
 
That being said, the Turing cards usually have only about 10% more to give. They're already running at between 85-90% of their efficiency, when running optimally.
A difference that's smaller than running Linux vs Windows for Nvidia GPU folding.
I also have my doubts about CUDA. It already works in Windows, but gives some strange results; like, sometimes resources of one card are allocated to another.
Meaning, one WU will be done faster, while the other is done slower.
The way they can be optimized, is by re-routing part of a high atom WU card to a low atom WU card.
However, there will be additional PCIE latencies, meaning the high atom WU will be running about 10% slower. So just hoping that the secondary GPU can do more than 10% workload.
I'm not confident that CUDA is a good solution, as it has many drawbacks.
Perhaps in a few years, when the technology has ripened...

Cool GTX
@ ProDigit
 Might be more energy efficient ... but PPD - is about - Bonus Points - and they RULE ...  that means Speed is the Most important optimization.  
This is not a "for profit model" like Coin folds have.  True, conservative Folders might benefit from that angle ... lower electric bill
 

Might be ok, if you're having a million bucks to throw at RTX 2080Tis, or Titans, running at their full rated power consumption.
But if you do the math, running the RTX 2080Ti at 180W instead of the full 300W, gets me less than 10% PPD loss. Probably closer to 2-5% PPD loss.
That's below 200k PPD, but for the sake of argument, let's say it's about 300k PPD per card.
Have 3 of them in a system, that's much less than 1M PPD lower performance, but at a power consumption of just 540W instead of 900W for all GPUs. (add system power to it, and it's 650W VS 1000W).
Add 1 RTX 2080Ti to the motherboard, and you'd be folding >1M PPD higher than before, still at 180W less than stock.
If your mobo supports it, you could add another 2080Ti, consume the same amount of power as a stock setup, but at 3,5 to 4M more PPD.
Speed isn't always the answer, when the same can be done by adding cards in parallel.
Most people probably are somewhat affected by their folding power consumption, either by the bill, or by the maximum amount of current they can draw on a system (eg: Solar panel systems). 
 

Starting to sound more like a Mining Thread now.