Try manually setting all the XMP profile timings while using a lower mem speed such as 3200.  See if you're stable with that.  If so, bump it up to say 3600 and test it out. 
 
Most likely, trying to run up at speeds that high, you'll need to increase some voltages a bit.  Possibly the dimm voltage itself will need a bump up as well as VSA to name a couple.

bdary
Try manually setting all the XMP profile timings while using a lower mem speed such as 3200.  See if you're stable with that.  If so, bump it up to say 3600 and test it out. 
 
Most likely, trying to run up at speeds that high, you'll need to increase some voltages a bit.  Possibly the dimm voltage itself will need a bump up as well as VSA to name a couple.

Appreciate the response for sure, I guess i could better explain it as the system itself was stable, but there was a certain program that would crash out until I dropped back the speeds, I did try and kick it up to 3600 today to see if we have any issues, Just had never seen a program itself not work right.  Usually the system isn't stable in my experience. 
 
When it comes to timings for RAM it seems the BIOS puts the tRCD/tRP timings under the same setting in the BIOS, are these normally the same?

Slakr1178

bdary
Try manually setting all the XMP profile timings while using a lower mem speed such as 3200.  See if you're stable with that.  If so, bump it up to say 3600 and test it out. 
 
Most likely, trying to run up at speeds that high, you'll need to increase some voltages a bit.  Possibly the dimm voltage itself will need a bump up as well as VSA to name a couple.

Appreciate the response for sure, I guess i could better explain it as the system itself was stable, but there was a certain program that would crash out until I dropped back the speeds, I did try and kick it up to 3600 today to see if we have any issues, Just had never seen a program itself not work right.  Usually the system isn't stable in my experience. 
 
When it comes to timings for RAM it seems the BIOS puts the tRCD/tRP timings under the same setting in the BIOS, are these normally the same?

If even one program causes instability, then it's probably close, but not quite totally stable.  You may want to try increasing your Dimm voltage a tick or two.  Say the rated dimm voltage is 1.35v, try 1.36 or 1.37v.  You could also try adding 50mV of VSA voltage.
 
If that doesn't work, your IMC (as mentioned above) just might not be strong enough for that speed.  Find the highest speed you can run at while stable. ie, 3400, 3600.  What you could do for timings if you can't run at the rated 4000 speed is set the XMP profile, write down all the settings/timings it sets.  Then set your mem speed manually to whatever you can run at and manually set the timings/settings you wrote down earlier.