My boot-up time into Windows 10 is so slow. What can I do to optimize my bootup time? I also notice my keyboard and mouse wait to turn on after I'm in Windows. Odd! 

In addition has your PC always done this or only recently?

Digital_Fuzion
My boot-up time into Windows 10 is so slow. What can I do to optimize my bootup time? I also notice my keyboard and mouse wait to turn on after I'm in Windows. Odd! 

Define slow? An extra 10 seconds? A minute? Two? 
 
Installing the OS on an SSD is the best thing you can do for boot times. Next, the BIOS has options called "fast boot", which can speed up how fast the system hands off to the OS. One of the UEFI settings that affects boot times is USB initialization... this can be set to disable, partially enable, or fully enable USB devices while booting. When not initialized or only partially-initialized, once the UEFI hands off control to the OS the OS itself must fully initialize the USB which is why peripherals power off/on again briefly once the OS loads. If you find your motherboard manual you can likely find the setting options for USB devices detailed in there specific to your board.

SherwinXL7
nuke your install and do it again

my only troublefree method


 

I'm always using sleep to avoid cold start.

My pc updated to the new update ending in KBxxxx1330. 1330 introduced gaming performance drops and stutters. My pc booted slower like usually it's ready in 20 seconds. With the update It also stuttered and I was getting less fps with more frame drops. As soon as I uninstalled that update all was back to normal. With an ssd I just power my pc down everytime I walk away and don't intend to come back for awhile. Sleep sucks and messes things up for no good reason. An SSD makes sleep obsolete. I hear the 1330 update affects multi monitor systems more. Which mine is.

Probably the settings of the bios were switch at some point? Most SSD preferred setting is ACHI

vanshion
I'm always using sleep to avoid cold start.

That might be the problem. You need to completely restart you computer every so often.
 

Flushes RAM

Your computer's random access memory (RAM) is also known as volatile memory, because it's constantly in flux -- as opposed to solid-state memory, such as your hard drive. Your RAM handles lots of different short-term tasks and data, like running processes and holding program values. Rebooting your computer flushes out all this information, allowing your device to start anew and helping it run faster and more efficiently.
 

Stops Memory Leaks

Memory leaks occur when a program doesn't close properly. Every program that runs on your computer uses memory (usually RAM) while it's open. When you close the program, that memory should return to your computer. Outdated, overused or glitchy programs, however, can have memory leaks, which occur when memory isn't returned to the computer. Rebooting your computer each night can help prevent memory leaks from occurring.
 

Fixes Small Errors

Many computer users are unaware that when they reboot their computer, it runs diagnostics on itself, automatically fixing minor errors. These errors can range from buggy or glitchy applications to problems with the RAM. This is why you'll often find that when your computer freezes, or has a problem you don't know how to fix, simply restarting resolves the issue.
 

Installs Updates

Every piece of software on your computer has the potential to receive updates, which can add new features to an application or fix issues that occurred with older versions. In fact, Microsoft releases new updates for its components on the second Tuesday of every month, known as "Patch Tuesday." Often times, you must restart your computer to download and install the necessary updates and patches that help it run quickly and smoothly.

This might come as a shocker, but he already has a SSD installed in his system.  Come on spammers, try harder.

ty_ger07
Come on spammers, try harder.

What is with this spammer name-calling?  Don't be such a rude boy.

Check for applications that are starting in windows startup process

Try a restart. That is Windows button -> restart. (not turn off -> turn on, but an actual restart)
It makes sure it's a 'fresh' restart. Also, remove any useless start up apps (windows -> search for "startup apps")

Feels like with every update, the OS gets slower and slower.

W10 has startup app manager and anything below has msconfig to help manage your apps. I believe it tells you processing cycles.

Download CCleaner and check the startup boot applications - remove as required.