So after trialing several different EVGA cards, installing, uninstalling, DDU, everything, I think I found a solution to the RGB LED settings not saving and not applying on reboot.
-I set the RGB LED’s the way I wanted them
-Went into settings
-Set a hotkey, a random key
-Uncheck Apply previous settings, recheck it
-Hit Apply
-Hit a new profile number on the right you’ve never used before
-Click Save
-Click that profile number again
-Click Save again
Shutdown (don’t restart)
Reboot and you should see the LED setting you set as soon as the system POST, even before booting into windows.