Posting here in case anyone has experienced this.

Triple screen user with 3 Benq 27" monitors and a EVGA 2080TiFTW3. Latest drivers and everything has been working fine for years until the last few months when the screen on the right stopped booting up when awaking from sleep. If I plug/unplug the monitor it comes alive.  Motherboard is an ASUS Maximus Hero IX Z270.

Changed the cables, no change. Then it moved to the middle monitor where it won't wake up from sleep and you have to plug/unplug it to wake up. I also on occasion have a scenario where if I wake from sleep none of the monitors will wake (all show signal not found).

If you go into the NVIDIA control panel, you can see that even after pluggging/unplugging the affected monitor only 2/3 monitors show up or the resolution is off (shows 3840xsomething instead of 5760x1080).

Any ideas on what's causing this? Not cable related. Not monitor related from what I can tell.

Graphics card issue?

Sajin
You've tried reinstalling the drivers after cleaning them out with ddu? Does the issue occur with a different video card?

 
Yep, tried doing a clean uninstall and reinstall through NVIDIA as well as through ddu.  I've also tried reverting back to previous drivers and that doesn't seem to be working.  I even disabled the quick boot in BIOS to see if that changed anything.  It's really strange.