Space Siege won't start, how to fix this problem? Problem as shown in the image.

RushXTC
Try this : 
 
https://steamcommunity.com/sharedfiles/filedetails/?id=759656491

You have not given any information - for us to work with

What are your system specs ?
 
OS details ?
 
What have You already Tried ?

NVIDIA PhysX System Software Older Driver
Version: 9.18.0907 Release Date: 2018.10.08
Operating System:
Windows 8.1 32-bit, Windows 10 32-bit, Windows 8.1 64-bit, Windows Vista 64-bit, Windows XP, Windows 8 32-bit, Windows 7 32-bit, Windows 8 64-bit, Windows XP 64-bit, Windows 10 64-bit, Windows Vista, Windows 7 64-bit.

Quatro P1000 Drivers do not come with NVIDIA PhysX System Software for whatever reason.
 
•This version of the PhysX System software provides updates necessary for some games to run PhysX content properly on Turing GPUs. These include Batman Arkham Knight and the PLA(Passion Leads Army) Benchmark.
•Includes the latest PhysX runtime builds to support all released PhysX content.
•Supports NVIDIA PhysX acceleration on all GeForce 9‑series, and 100‑series to 2000‑series GPUs with a minimum of 256MB dedicated graphics memory.
Note: Some applications may have higher minimum requirements.
•Supports NVIDIA PhysX acceleration on GeForce for SDK versions 2.7.1, 2.7.3, 2.7.4, 2.7.5, 2.7.6, 2.8.0, 2.8.1, 2.8.3, 2.8.4, and above.
•Supports control of your GPU PhysX configuration from the NVIDIA display driver control panel.
•Note: For games that use SDK versions before 2.7.1 the PhysX Legacy Installer must also be installed. These are games that were released around the end of 2007 or earlier. (AGEIA titles) Examples of these games include Cell Factor, Clive baker’s Jericho, Gears of War, Pirates of the Burning Sea, Switch Ball and Velvet Assassin.
The PhysX Legacy Installer is available here: PhysX_System_Software_Legacy_Driver.
 
NVIDIA PhysX System Software Newest Driver
Version: 9.19.0218 Release Date: 2019.03.08
Operating System:
Windows 7 64-bit, Windows Vista 64-bit, Windows 8.1 32-bit, Windows 8.1 64-bit, Windows 8 64-bit, Windows 7 32-bit, Windows 10 64-bit, Windows XP 64-bit, Windows Vista, Windows 10 32-bit, Windows 8 32-bit, Windows XP
   (I am Running Windows 10 1903 with this Driver) Quatro P1000 Graphics Card.
 •This version of the PhysX System software provides updates necessary for some games to run PhysX content properly on Turing GPUs.
These include Metro Last Light, Metro 2033 and Assassins Creed IV Black Flag.
•Includes the latest PhysX runtime builds to support all released PhysX content.
•Supports NVIDIA PhysX acceleration on all GeForce 9‑series, and 100‑series to 2000‑series GPUs with a minimum of 256MB dedicated graphics memory. Note: Some applications may have higher minimum requirements.
•Supports NVIDIA PhysX acceleration on GeForce for SDK versions 2.7.1, 2.7.3, 2.7.4, 2.7.5, 2.7.6, 2.8.0, 2.8.1, 2.8.3, 2.8.4, and above.
•Supports control of your GPU PhysX configuration from the NVIDIA display driver control panel.
•Updates the digital signature of the installed DLLs.
•Note: For games that use SDK versions before 2.7.1 the PhysX Legacy Installer must also be installed. These are games that were released around the end of 2007 or earlier. (AGEIA titles) Examples of these games include Cell Factor, Clive baker’s Jericho, Gears of War, Pirates of the Burning Sea, Switch Ball and Velvet Assassin. The PhysX Legacy Installer is available here: PhysX_System_Software_Legacy_Driver.