First, calm down, you will get edited and possible banned for vulgarities. I know it can be frustrating, but you agree to the TOS When you joined, so please remain semi professional in your responses.

I am sure you aren't the only person in the whole wide world that had this problem, I can however assure you that every person I'm the world that does have the problem isn't looking right here on your watch. When people that see this thread notice the same problem, they will come forth, but until then, getting bent out of shape 15 hours after your very first post is doing you no good and may net you less responses. You have to give people a chance to see it.

Your posts will be edited to remove vulgarities.

I do not know what the problem is unfortunately. When you say, "it makes me switch back to profile one" areally you saying it automatically does it? If so, what are the clocks, since they are underclocked?

So far your first description is vague and your second is just anger which does you no good to post.

Sorry I was pretty heated and now that I am over being butthurt we can get done to business. 1profile is oc profile  power target is 100%, gpu temp target is 83c, gpu clock offset +75MHz, mem clock offset +110MHz. Profile 2: 1st 2 are the same. gpu clock is -105MHz and me clock is -502MHz. When I launch any game its will always switch to profile 1. no matter what the clock on profile 1 and 2 is its always changes to 1 even is I set them both to the same exact same settings. 

Would you mind trying this with EVGA Precision X 4.2.1 just to see if the card is doing it just off of memory? My cards act weird even after I fully uninstall precision x16 sometimes.

This is my copy I always use. I would fully remove precision x16 before trying it https://www.dropbox.com/s...nX_Setup_421._exe?dl=0

This isn't an answer, obviously, but definitely want to see what it does.

Use GPUz to monitor the speeds. If the speeds aren't changing, then it is working.

It may just be some random anamoly honestly. Computers are possessed.

Mine would randomly change the leds on my cards, and then occasionally apply an overclocking profile at complete random, and it also labels every card wrong in sli, except for card 1. I have no idea what they are doing, as I am not a software developer, but I would love the know what is going on as well.