Still love this old board and I am hoping to squeeze out 2-3 more years of service. I'm just having an odd issue more and more frequently lately:

A random, hard lock during the boot process from a fully powered off state.

Almost always before the very first BIOS POST screen, but one time it even froze following it, but prior to showing the AHCI screen.
 
I of course am using the final official BIOS, cleanly flashed and tried all default settings.

The error codes on the board's LED are random. They freeze at FF, F3, F6, F7, 68, or sometimes still showing temperature of 24-25 idle.
 
I have no input, no visual, and I don't even hear the audible BEEP noise that the POST screen would usually be indicated by.
 
I have 6 sticks of 2GB RAM, and I tried various combinations of 1 or 2 sticks, in the appropriate slots for using so few. Boot failures still occurred, no matter the combination or which sticks I chose. I also cleaned all 6 sticks contacts with rubbing alcohol and paper towel.
 
I'm looking for any suggestions. It's not a big deal because it almost always boots fine after I hold power for 5 seconds and power on again.

the CMOS battery was on my list of things to try but I figured it was the least likely fix. But I'll remember to pickup a new one soon.
 
I'd hate to learn this PSU is at fault. It's quite overkill for this machine but I won it from a podcast I was a longtime listener of. I....think I still have my old PSU somewhere....

If all else fails pick up a used EVGA X58 motherboard. I just saw a classified X58 on ebay for 75 bucks. I'm sure there are other sources from which to buy one as well. 

So I narrowed the issue down to a legacy component of some kind. I've not had a boot issue for 2 months, and likely 70 boot ups. I was keeping track of everything I was trying and scratching each one off as I encountered another boot failure. The last thing I tried was I disabled all the legacy ports on the motherboard I wasn't using. Stuff like firewire, the com port, onboard audio, and the two extra sata controllers for ports 6/7 and 8/9 (I still use ports 0-5). The issue must have been with one of these. I hope this tip helps someone else out there. Hopefully I get a few more years out of this workhorse.

rjohnson11
The only problem I had with that motherboard was the marvell controller driver for the SATA ports you disabled

Nice. Although my issue was before even seeing a POST screen, so that's long before any operating system drivers come into play.