I have a EVGA GeForce GTX 1080 Ti FTW3 GAMING, 11G-P4-6696-KR, 11GB GDDR5X, iCX Technology - 9 Thermal Sensors & RGB LED G/P/M.  Only one Display Port is working on the card.  Looking at the rear of my case the working DP is the second one from the left.  I have two identical ASUS monitors PA249.  Both monitors on my old computer works fine connected to the two DPs on the video card (AMD R390).  Hooking up any of my two monitors to the bad connectors don't work so it's not a dual monitor issue.
 
When connected to the bad DP connectors on the card the monitor fails to acquire a DP signal. I tried all arrangements of my two monitors on the two ports that aren't working.  I've ruled out the monitors and the cables.  For the time being I have one of my monitors hooked up to the DVI connector on the card.
 
Other than having a defective card is there something I am missing?  I have the latest BIOS for the card as well as for my motherboard.

Turning off the monitor, plugging the cable into each of the two DP ports that aren't working, then powering on the monitor did nothing.  The monitor couldn't finds a DP signal.  As I said, the one DP that works I can pull the plug out, lose the signal, then plug it back in and the monitor comes alive again.
 
Perhaps the card isn't seated correctly.  Is there something on the card itself that controls the DPs?

AHowes
Ok well what about changing the input on the monitor. You said dvi is working so prob you need to change the input on the monitor to display port.

Of course I had my monitors set for DP.  Just like I had to set one to DVI in order for both monitors to work.
 
I reseated the card which didn't help.  I even moved it down a slot which also did nothing.  I even tested with the BIOS switch set to Master and then Slave.  My thinking here was that the BIOS versions might be different.  I didn't check the version number but neither way fixed the problem.  It's go to be defective.

Time to send it home.

did you actually go into the nvidia control panel and enable the screens?

There is no screen to setup.  Using the 'bad' displayports is like not having any monitor hooked up at all.  If the GFX BIOS doesn't see the monitors then Windows won't see it therefore no screen. 

squall-leonhart
thats not how any of this works.

If your GPU doesn't detect a monitor, neither will Windows... is how it works. Maybe the wording could have been better.

HeavyHemi

squall-leonhart
thats not how any of this works.

If your GPU doesn't detect a monitor, neither will Windows... is how it works. Maybe the wording could have been better.

Not all displayports will display POST info, mainboard and bios/uefi depending.
 
You haven't displayed any screenshots of the device manager or moninfo's data, and desktop installations do not automatically enable new screens as they are connected.