I recently bought the Nu Audio sound card on Amazon and I can't get the software to work at all. Any time I try to install the drivers, I get an error message telling me they did not install correctly and I need to restart my computer and try again (this does nothing). Every driver version gives me this same issue. Before anyone asks, fast startup is off, it is connected with a 5 wire SATA cable, and the logo lights up on the side when I turn the computer on. I have no other pcie slots to use, but I know the one it is in works (more on that below).
 
The card shows up in the device manager, but it is under "other devices" instead of "audio inputs and outputs". If I click on it, it says the device is not configured correctly. Any attempts to update the drivers as it suggests results in it saying it found the drivers I need, but couldn't install them.
 
I have gotten it to work once when I did a system restore point to before I attempted to install the drivers. The computer took about 30 minutes to start up, but when it did it was already selected as the default audio device and everything was working fine. It appeared under "audio inputs and outputs" and I could hear sound.
 
Windows had installed whatever drivers it had, so I went on the EVGA website and tried to install those drivers again just in case it was still required. Unfortunately, the drivers ruined everything and it no longer appeared under the right section in the device manager. It was back to being under "other devices". I couldn't hear anything anymore, and I started getting the same errors as shown in the pictures above. It is no longer an option I can select for audio. So I was basically back where I was in the beginning. For whatever reason, Windows got rid of the restore point, so I can't use that method again.
 
I know the audio card itself works, but the software is a complete mess and ruins everything. This has to be the most frustrating software I have ever come across.
 
UPDATE: I managed to fix it again, but there's no way I can download and use the control software from the website without it messing up the card. I basically have to stick with the default settings.
 
Specs:
Gigabyte X570 Aorus Pro Wifi
AMD Ryzen 9 3900x
Zotac 2060 Super
G.Skill Trident Z 32gb DDR4-3200
Corsair RM 850

With an X570, you may need to disable C-States in the BIOS, and to try setting the PCIe slot to PCIe 3 or lower.  See if that helps.

It will show up as a USB device due to the card's design using a USB-based XMOS chip, but it uses an ASMedia USB to PCIe bridge chip to connect via PCIe.
 
You can still set the PCIe slot configuration even lower to PCIe Gen 1, and the card will work fine. 
 
Your board has a Realtek controller, and we've advised these steps before.  Remove the EVGA NU Audio drivers first, then use Display Driver Uninstaller to remove the Realtek software.  Reboot, and try to reinstall the NU Audio Drivers to see if it works.  If that still doesn't work, try to directly update the ASMedia USB 3.0 driver with this:  https://cdn.evga.com/nuaudiocard/ASMUSBHost_V116591WHQL.zip.
 
Also, if you have the Gigabyte USB Blocker software installed, I'd probably suggest removing that, as well.

FireHazard01
I still couldn't get the drivers to install correctly and the audio card is back to being listed under "other devices" again. I had set the configuration to gen 1. I uninstalled Realtek with DDU and the only sound options left are: (S/PDIF) high definition audio device, NVIDIA high definition audio, and NVIDIA virtual audio device. Apparently I already had the ASMedia driver installed because the only options were repair and uninstall. I tried the repair option, then I uninstalled and reinstalled it with no change. I never installed the USB blocker software so that wasn't an issue.
 
There was still the problem of some games not having sound due to the USB and another one that wouldn't start at all because it "failed to initialize sound card", although I don't know if that problem would be fixed by getting the drivers to install. Unless there are any more possible solutions, I may end up having to get rid of the card. I've never had drivers just refuse to install like this before.

Go to start, Right Click, This PC, Property's, Advanced System Settings, Hardware TAB, Device Installation Settings, Select No and save.  Disable NVIDIA high definition audio & NVIDIA virtual audio and Uninstall and ASMedia driver in device manager. Uninstall and delete EVGA Software and Driver, Go in Program Files and Delete EVGA, EVGA NuAudio and EVGA_NahimicAPI Folders. Also EVGA Folder in C./Users/USERNAME/AppData/Local Reboot and Disco from internet to keep windows update from searching from drivers. Install Driver 2.1.7. Reboot. Test audio and make sure Nvidia's Audio software is still disabled. Hope fully this works.
 

Try resetting windows. Had a user have as hard as a time as you are having do this and seem to work. Start, type reset this PC, select get started, select keep my files then let it run.

cyber44030
Try resetting windows. Had a user have as hard as a time as you are having do this and seem to work. Start, type reset this PC, select get started, select keep my files then let it run.

That's always an option, and it works more often than we'd all like to admit (I'm just talking about my own personal experience with plenty of other devices), but it's not usually the first thing I want to ask customers to do, unless it's a brand new install of Windows or the customer has a spare hard drive to test a clean install of Windows.
 
I'm going to have our Audio team look at the issues here.  I've been in Motherboard land for the last month or so, so I'll check to see if we have any diagnostic stuff we can send the OP to try to pare this down a little.