Still having issues with the 6.2.7 XOC. I set up how I like my fans on the 1080Ti ICX, also have the HWM open and have the GPU power and Mem all checked like normal, also have the CPU package and framerate also clicked.
Click ok to save and go about my gaming. Turn off the computer to do some other things come back a few hours later and I have to redo everything again. 
Not sure why we can't figure this out by now, it's been a problem for a long time. I was moving and had the computer packed up for 2 months and come back to see we are still having issues. Is this a W10 compatibility issue with XOC?
Was playing some Fortnite and got an alarm about my GPU hitting 82c come to find out that my settings did not save again, good thing it was only for like 20sec @ that temp as I had to get out of the game to reset everything.
Things I have done
Uninstalled files and folders, restart and reinstalled 6.2.7 and no fix
The same process and installed 6.2.3 and still the same thing
Using RevoUninstaller to uninstall, I have also tried to use the Apps & Features and still the same thing.
 
8700K 
ROG MAXIMUS X HERO (WI-FI AC)
Gskill F4-3200C16-16GTZR
Corsair 860i
Evga 1080Ti ICX
NZXT X72 Cooler
W10Pro Ver 1803 OS build 17134.165

That seem to do it, setting everything and then closing/reopening it worked.

bob16314
That's been an issue (bug) for a long time now..After making any changes in Precision, OSD or HWM settings and clicking 'OK' where applicable, close and open Precision again to make sure they remain..Most changes won't get written/saved to Precision's .cfg files unless Precision is closed..If you want to load an overclock when Precision runs, enable 'Apply previous settings on load' and click OK, then close and open Precision again..If you want Precision to load with Windows, enable 'Start With OS', click OK, then close and open Precision again.

Having 'Fast startup' enabled in the Windows Power Options will not save the settings on a cold boot unless Precision is closed so the settings get written to the .cfg files.

If you make changes in HWM, always close HWM before closing Precision.

See how that works out for you..Works for me.

Thanks for helping him out Bob.