Uninstall Precision XOC and restart your PC..Then delete the Precision XOC and LED Sync folders located in the Program Files (x86)\EVGA folder..Then install Precision XOC again and set it up from scratch..Roll from there.

Thanks... I just went back to 6.2.3 and everything works fine. I'll just stay here for a while.

Something happen to EVGA Precision XOC when Microsoft release update Win 10 1803.
I'm using version 6.2.7.  Sometimes it works. Sometimes it don't.
I've found that if OSD does not work.  I use Task manager and shut down Microsoft Edge(you will see a Green Leaf Icon when MS Edge is not an active window) then OSD will work.  I don't even need to restart Precison XOC to get the OSD to work.

Well I was little quick with that other post. The problem still exists with v1803 and any EVGA version I've tried. I stopped Edge with the green leaf in task manager. I've closed Edge by open and then closing it and it's still a hit or miss situation whether the OSD will come on during a game. It may work 3 or 4 times in a row (why I thought it was fixed) and then it won't come on again.
Still looking for a solution to this one.

Updated current install from 1709 where the OSD worked 100% of the time I asked it to be running. There is obviously something going on between the 1803 update and Precision XOC. That the OSD sometimes will work with both 6.2.3 and 6.2.7 would indicate the problem is with 1803 and not the EVGA software. It looked like shutting down Edge was the problem but it wasn't, at least for me. Something else is running or not running in the background to be causing this. Or who knows, it could be anything. It might be as simple as changing one of the new settings in 1803??? 
One thing I did notice is that I had the HWM open on the desktop (but not visible during the game) is when the game was shutdown, FPS was still showing 0 when the OSD didn't appear but when it was working, the FPS in the HWM was showing correctly at 165 FPS while the game was running.

Thanks, I download and install the Nvidia drivers myself from their website when they become available. I've removed and reinstalled XOC using Revo uninstall. No help. I have no intention of doing a clean reinstall of the OS. Now that someone is aware there is a problem, it may be looked into. In the meantime, I really don't need the OSD but it is nice to have running just for something to keep an eye on. As long as the fan control is keeping the GPU (GTX1080) cool, which it has been, then waiting for a fix is no problem for me... Thanks again.

I also can confirm, turning off Edge allowed my OSD to work in win 10. Would not work until i killed it in task manager

I checked as thorough as I could and I don't see Edge anywhere in startup services. With 1803, after startup, it does appear in task manager with a green leaf which means it's suspended until opened. By ending that task the OSD will work. After Edge is opened and closed normally, the OSD does NOT work. If you close Edge through task manager the OSD will work. So whether Edge is loading at start is really not the point. If you use Edge and don't shut it down in task manager, the OSD won't work. At least this is the case with me, 90steve09 and coolhand5150 who also confirm this same problem and work around to fix it.
You may get other confirmations but it depends on whether others having this problem are using this forum, read this thread and respond.

I guess I'm going to keep on posting... I usually let my computer run 24/7. When I couldn't get the OSD to work today, I finally decided to reboot. Immediately after restarting, I closed Edge (green leaf) in task manager and tried a game. The OSD worked. I'm really confused now but still pretty sure Edge had something to do with this.

Want to chime in here.  I'm a computer engineer and gave up after trying just about everything to get Precision OC to work.   The OSD will not turn on for anything.
 
uninstalled:
nvidia drivers
precision oc - delete reg keys and program files folder
rebooted
re-install drivers
rebooted
reinstalled latest precision oc
rebooted
reset everything to defaults, still doesnt work.
 
I'm about to give up here.