Yes you can indeed run 4 way 580s. As for what board?
 
On X58 it's only the 4 Way Classified if I remember right, but on X79 there's a lot of options. Namely, the EVGA X79 Classified, Gigabyte X79 UD7, and ASUS X79 Rampage IV Extreme.

 This thread (the original one) is what took me over to the cooler side.

Know what's funny? We're now on page 295, which are the cards we're all so well known for pushing hard. 

If I only had enough money to do this stuff. For me the hard part isn't the overclocking, its the working and saving up to buy this kind of equipment.

Looks Like to start off You need Four GTX 580's (Around $3000 worth), and an EVGA MB capable of Handling the 4 Cards to Start with.
 
It's Kinda Funny that ONE GTX 580 will beat My old Quad SLI GTX 295 Vantage Score!

Damn, Halo ninja'd me... i noticed the 295 thing too.

Welcome back Hallow! Sorry to hear about the healh problems. I havent overclocked in over a year, been to busy making waterblocks, and recently doing a complete CNC machine teardown & also building a second much larger CNC.

Thanks Nate,
 
Sometimes Life Throws You a Curve Ball, But at Least You're still able to run the bases!
 
Ditto on the Not Overclocking for a Long Time, But I'll be trying to start up again soon, albeit Not Full Tilt until I watch "The Other Top Dawgs" and take some Notes!
 
Also, There seems to be a Lot of "Talk" about ATI Radeon's 7970 being 1.6X Faster than the EVGA GTX 580 that I want to watch and learn about (Competition.......Competition, it Never Stops, Does it?)

Mhm the 7970 is supposed to be faster. I may think about it, but for now I'll stay with what I have. Might end up dumping the bstock 295 so that I can fund my pots faster. Let me know if any of you guys are interested, it has a heatkiller block on it. This is one that can do 800/linked/1200 on 1200mV I believe. I'm not for sure selling yet, but with the block I was thinking like $225 shipped or so.

http://valid.canardpc.com/show_oc.php?id=2162586
 
Not bad, trying to get it stable, hasn't crashed yet though.