My 4P and 2Ps are Running BOINC Projects along with Folding on Graphics Cards Mostly GTX 980 and now a par of GTX 1080 Cards. I even have a par of AMD R9 290X Graphics Cards that Fold. All my Graphics Cards also run BOINC GPU Projects.
I stopped Folding on CPU when the BigAdv Ended but the 4Ps can be used on a lot of different BOINC CPU Projects like WCG the closest program to Folding at Home.
As far as GPU to Fold on they say GTX 780 and above but for me any Maxell or Pascal Card is the way to go now at least with Core 21 the current GPU Program. My 290X are not so bad on Core 21 but did much better with Core 17.
You will really like them 1080 Hydro Coppers set the Client to use client-type = advanced
Stay on Driver 373.06 for now all newer Drivers are not working on the Maxwell and Pascal Graphics Cards.
Welcome Back to the Fold, PS You just missed this years
TZC