I have the 1080 SC in a Fractal Design S Nano (read ITX case) with the ACX 3.0 cooler. Temps were 81/82C under load with fans at 100%. I wanted more quiet and cool, so ordered the thermal mod kit and the AIO hybrid cooler. The thermal mod kit shipped Monday and received on Wednesday!
I installed the hybrid cooler using all the pads from the thermal mod kit, including the narrow pad for the baseplate. I opted to cover the VRMs with the narrow pad even though there is a cutout on the baseplate for blower air cooling. The idea was to put the edges of each narrow pad under the baseplate. This should channel heat into the baseplate more efficiently, although I did not test the temp results of the VRMs specifically.
Without overclocking: Unigen Heaven High @ 3440x1440:
Clocks:
GPU: 2012MHz
Memory:5005MHz
Temps:
Ambient: 25.5 C
GPU (Case Fans Max: Can't hear over pc audio) 45 C
GPU (Case Fans Custom Quiet) 50C
Extremely happy with the results!