link:
 
https://www.ekwb.com/shop/ek-xres-140-revo-d5-pwm-incl-pump
 
https://www.ekwb.com/shop/ek-coolstream-ce-560-quad
 
 Would i be able to do 2 CPU's, 2 GPU's with said?

You should be fine with a moderate overclock on all parts as long as you use the Vardar F3 or F4 fans that rad is optimized for high static pressure fans and their very own Vardars are just what the doctor ordered. This will not be a quiet PC under load especially if overclocked but the F3's are the quietest of the 140mm fans that can do 2000RPM.
 
Give this a read EK Vardar F3-140ER 140mm fan

Think the D5 xres would push two 560 rads, two gpus and two cpus?

IMHO No go with two Xres or a Dual D5 top.

Of course if you want max performance, you'll run your fans and pump at max, but the trade off is more overall system power (fans and pump) and noise. According to thermalbench.com reviews of the 560, the 560 will keep your loop at +8.5C above ambient 1600RPM (for about 500W of power). With 2 CPU (100W each) and 2 GPU (200W each), you'll be pushing the system close that it may not be able to remove all the heat in and therefore you'll see your loop temp climb and maybe run away. 
 
Configure your system as you want (with OC), run it at max thermal load (CPU+GPU) and connect meter to the system (like a kill-a-watt meter). Subtract 15% (fans, PS efficiency, and other peripherals) and that is the power you need to remove. If that number is below 450W, then you should be good with your config.