Hi EVGA
I have some screen mess problems for watching youtube videos.
Whenever 4K OR 1080p, google chrome or edge, 2 monitor or 1 monitor, full screen or not, it will randomly show up.
System information
Window 10 Professional 
Graphic card: EVGA GeForce GTX 1080 SC GAMING ACX 3.0, 08G-P4-6183-KR, 8GB GDDR5X, LED, DX12 OSD Support (PXOC)
Graphic card drive: 3.0.7.34
CPU: I7-6800K
RAM: 64GB
Browser: Google Chrome 54.0.2840.71 m, Edge Microsoft Edge 38.14393.0.0
How can I fix it? is physical problem or software problem?

   

 
UPDATE
just one plug-in fix all problem
h264ify
play youtube with H.264 instead of VP8/VP9 

Change power management mode inside the nvidia control panel from optimal to adaptive. Reboot PC. Retest.

Sajin
Change power management mode inside the nvidia control panel from optimal to adaptive. Reboot PC. Retest.

I don't have this option

danieljos

Sajin
Change power management mode inside the nvidia control panel from optimal to adaptive. Reboot PC. Retest.

I don't have this option

Their was a Flash Player update this week.

I don't have  power management mode this option

danieljos
I don't have  power management mode this option

 

bcavnaugh

danieljos

Sajin
Change power management mode inside the nvidia control panel from optimal to adaptive. Reboot PC. Retest.

I don't have this option

Their was a Flash Player update this week.

I have two 4K monitors, One of those use HDMI, another use DisplayPort.
SO one of those is 3840X2160 30HZ, which is  DELL UP2414Q, another is 3840X2160 60HZ, which is LG 27.
Both of them have same problem, whatever my video plays on my bowers in each of them.
 
UPDATE
Still has this problem, even I set " Power management mode" to "adaptive"

The solution is to disable hardware acceleration in your browser.

UPDATE
Still has this problem, even I set " Power management mode" to "adaptive"
 
After you made this change above did you restart your computer?
 
Or use IE 11 as I do on my Windows 10 Rig.
Or at least test with IE 11 (This is the default in IE 11 disable hardware acceleration that is)
I still never found this setting in EDGE on Windows 10.

bcavnaugh
UPDATE
Still has this problem, even I set " Power management mode" to "adaptive"
 
After you made this change above did you restart your computer?
 
Or use IE 11 as I do on my Windows 10 Rig.
Or at least test with IE 11 (This is the default in IE 11 disable hardware acceleration that is)
I still never found this setting in EDGE on Windows 10.

Still happening....no anything become better, even I changed my power mode to the FULL power, still
 
and I tried to disable hardware acceleration with my google chrome, but video will lost frame and very slow.
 
Are you 4K monitor? or 1080?