wizanhi
How interesting....  I can see where you can't get everything through the red circle.  I know I definately can't.  No opitcal drive so thats 1 less sata cable i would need to route but if i'm going to have 4-8 drives....probably won't have enough space. 

No issues with the cable for the 1080?  Looks like it had plenty of room from you picture but some reviews have complained about difficulty in wiring it.  

Does it look to have any restrictions on radiator thickness for the side mount?  Looks like the top can handle just about anything but can't tell how well the side will handle any thickness.