If you have issues saving profiles do the following:
1. Change your sliders to the position you want, or type the values and then ENTER
2. Click the Apply tab
3. Right click a profile number to save it with the current applied settings. To change an existing profile, right click to unload it, then right click again to save it.
4. Click the Default tab to delete all of the profiles.
The profile number highlights mean
Dark - Profile is inactive. Right-clicking the profile number toggles it as Active or Inactive. When you hover over the profile with your mouse, the last stored values will show.
White - Profile is active
Blue - Profile is selected
The interface is confusing because right-clicking doesn't actually delete the profile as the tool tip says. I spoke to EVGA support recently and they said they were working on creating better documentation for this