I set my Acer G257HU 1440Hz IPS at 22% brightness and leave the contrast and gamma alone. I do photography and that brightness level gives me accurate tones and brightness when I print (meaning what I see on my screen is what prints) Plus, I take the extra step of calibrating my color with a Colormunki Smile.
I am also running Win 10 which comes with Dx12 (even though it's not optimized)