I totally borked my Fallout 4 game. So I had to do a fresh install.

I was playing around with widescreen, but there are certain aspects (like the crafting menu) that is hard to get just right, so I went back to just running it on my center monitor. Somewhere along the line I screwed something in the ini file up and it stopped responding to my 360 controller. Yes, I am one of "
those" guys.

So the only way to correct to problem was to wipe everything out and reinstall. Fortunately, I didn't lose my saves as I back those up on a regular basis.