So, apparently 128(?) (or is it 117?) damage rifle scoped damage does not do that big of an impact on an enemy from far away. So, I took my bolt rifle that adds 10 energy damage with .308 rounds (.50 is more scarce than .308), with a regular "dot", and then I took my double shot bolt rifle and added the .50 rounds with an attached scope. That made a huge impressive change, and now, from a far distance, I do almost instant kills from such a great distance.
I put the difficulty on very hard, and it definitely adds a challenge. You definitely want to make sure you head shot them before they get up close. Definitely getting swarmed by those giant mosquitos adds a real challenge now.
Has anyone shot at a mini nuke being held by a super mutant? Good times...