Even with only 2 mods installed, load order could be part of it.
Yeah, I got hit with the update was well. I think it was mostly because Microsoft updated their NET framework which required an update on the part of the NMM. But if it's any consolation, I've been having more random crashes with the latest NMM as well. Though honestly, I think some of that is tied to load order.
I seriously need to go through my mods and do some weeding. Im now up to 211 mods and 238 plugins. So time to do some cleaning. Plus some research into learning how to combine things in FO4Edit.
And almost forgot. I started a new game. Still deciding if that was a good idea or not.