I've been messing about with SweetFX/Realshade with goes deeper into the games graphic settings and allows you to tweak alot of things. Since I don't really want the hassle of playing with all the settings, I'm just downloading settings that other have made.
This is Fallout 4 - Ultra Realistic Cine FX. Pretty subtle changes, but adds a bit more vibrancy and depth to things.
Before.
After
You can see Curie there in the black trench coat. She's limping because... I might have shot her in the knee for being annoying.