agent8
I can confirm that not only are companions immortal but some key characters can not be killed. Sometimes I will save just before an important decision comes up and I will play through it to see what will happen if I murder everyone in my sight for the fun of it. Or sometimes I will get as far away as I can and lob a grenade through a window with a bunch of friendly's standing around and then I hurry up and sit on a couch unarmed like this....

 
But unlike you Pinocchio her nose is tiny.

Zuhl3156
I keep killing both Toms, the real one and the Synth one. No sense in taking chances. Can't say how many times I have run into these two. Sometimes the real Tom has already been killed by the Synth replacement Tom. Another doofus I keep running into is that geek selling credit cards. No matter what I decide he calls me a Retard so I just kill him right off the bat any more. He keeps coming back from the dead though. Maybe he was a quintuplet or something. Definitely Zombie material. That sucker just won't stay dead.

Walking Dead maybe?

stalinx20

I like to buy my bullets from the diner. From time to time those dope dealers drop some stuff that's sellable.

It was that way for me also but now I don't see any targets to shoot there.

Dukman

Zuhl3156
Trashcan Carla was / used to be a roaming vendor until I started some Sanctuary quest or crossed paths with her. Now she seems like a permanent fixture in Sanctuary though she is supposed to travel between Sanctuary and some diner where the dope dealers hang out. http://fallout.wikia.com/wiki/Trashcan_Carla
 

 
I knew/know who she was.  I think what makes her show up is when you start doing the mini quests to build beds and stuff in Sanctuary.
 
  And yeah, she seems to hang around Sanctuary alot.  Before the 1.3 patch her brahmin would end up on the roof of the house that had all the tool benches.   I didn't actually know about that little diner until I restarted the game, then I managed to find it.  Killed the dope dealer.  Figured guns, bullets and other items were better to have around than a dope dealer.
 
  

 
It still does or inside the room also. I saw that and couldn't contain the laughter.

Yeah, I've seen that too.  
 
Stupid cow.  Get out of my living room.    
 
Okay, we're going at it again.  Any bets at how long it will be before I get dist...    Oh look. I don't remember that building.

Isabel is always sleeping no matter what time of day I go the The Mechanist's Lair so I went into 'sneak' mode and finally found Protecton's Gaze on her. I picked her pocket and took it and then that Eye-bot that guards her snitched me out! Boy, was she ever mad too! She activated her Stealthboy, stole Protectron's Gaze back from me and proceeded to tear me apart. Rather than kill her for a stupid laser pistol I loaded a previous save. I like Isabel because she reminds me of Abby on NCIS. Lesson to be learned: Don't mess with Isabel! She's vicious!

Tuesday, the 12th, Bethesda releases the next DLC. From what I have gathered it will be dealing with settlement building and allowing more options for it. One option is the planter box. I know a couple settlements that can use them.

whiskers54
Tuesday, the 12th, Bethesda releases the next DLC. From what I have gathered it will be dealing with settlement building and allowing more options for it. One option is the planter box. I know a couple settlements that can use them.

That's it? A planter box?

whiskers54
Tuesday, the 12th, Bethesda releases the next DLC. From what I have gathered it will be dealing with settlement building and allowing more options for it. One option is the planter box. I know a couple settlements that can use them.

That would be a good place to put Trashcan Carla.

Now what did she ever do to you?   
 
Wait...  I think I got it.   She turned you down!