Zuhl3156
I'm getting bored so I think it's about time I started a war and rub out some of the other factions like The Institute and BOS. I gotta clear the playing field a little.
turn on Survival. It's a new experience; you're no longer "god", and healing takes time. So, you have to run and hide behind objects until your health gets back up. I noticed more that I have to switch between weapons to take out enemies. I have to avoid flame throws. Enemy NPCs that have sniper rifles I have to avoid as well, and have to go around them to take them out. I have to use more of Buffout and Psycho with mentats more, while using the extra foods and stimpacks. Using stimpacks alone is not enough to take out enemies on survival mode, and I can't run full blitz at the enemy and be tank while taking all the damage. Then again, my character is made to do full damage, and is not a meat shield. Using Jet is a huge bonus in survival mode. If you start out a new character on survival mode, good luck.
And of course, you will have to ultimately continue to avoid any enemy NPC carrying a fat-man.
Never let a super mutant carrying a mini nuke hit you. You'll have to load the latest save.
Never let a grenade hit you, you may just die, resulting in the latest save.
Avoid taking on a turret firing at you. They can rip you apart, and you will be loading the latest save.
Avoid a super mutant with a mini gun. They'll cut through you like Jello, and... you'll be loading the latest save.
Bottom line, it takes a little more strategy and tactics to be used in a gun fight. Not to mention, the extra legendary NPCs, with the constant legendary items and armor being dropped

I ran into that giant super mutant that has a kart on the back of him. VATS with my sniper rifle barely put a dent in him. Grenades slightly took care of the issue, but it was the shotgun that did most, while in VATS. I had to run off into a building and hide, fortunately a group of brotherhood in a chopper were flying around, and distracted him before i could get the last couple shots off.