5.3.8 is up now, please try this if you were having OSD issues, especially in DX9 titles.

Looks like the same issues on my end.  No OSD in Skyrim or Fallout NV, at least.
 
Update (09202015 @ 0830):  OSD works in COD: Ghosts with a 60Hz 4K screen at 4K resolution.
Update (09202015 @ 1115):  OSD works in Metro: Last Light at 4K resolution.
Update (09202015 @ 1130):  OSD works in Shadow of Mordor at 4K.
Update (09282015 @ 0602):  OSD works in Sniper Elite III at 4K.
Update (10032015 @ 2021):  OSD NOT working in Fallout NV at 4K.
 
So, it is not working in Skyrim or Fallout NV (both DX9 games).

Game: Watch_Dogs Steam/Uplay latest version with DLC
 
Problem: Does not launch if PrecisionX 16 is loaded
 
hardware:
asrock z97x fatal1ty killer i7 4790k at stock
evga gtx 980 sc / gtx 980 ftw in SLI
Kingston HyperX Fury 16gb 1866MHz DD3 CL10

Far Cry 4 will not run with 5.3.8 at all, not just OSD.

Not working with Fallout 4.
 
[EDIT] Just had to update to latest version and it works now.

Macros
Not working with Fallout 4.
 
[EDIT] Just had to update to latest version and it works now.

Macros,
 
Can you please explain to me how you got it working? I can't get the OSD to work in Fallout 4. Using Nvidia Drivers 358.91 with Precision 5.3.10
 
http://steamcommunity.com/app/377160/discussions/0/496881136906528217/

The Witcher 3
on V 5.3.10

Witcher 3 no Osd an fps freezing up

Not sure if its Fallout 4 or the reshade/sweetfx causing this to happen but no OSD is showing up in Fallout 4.

Also I'm running the game at 2K DSR from my native 1920x1080. Maybe that's why it isn't working. (nope, just tried it, still doesn't work in fallout 4 at my native res)

-edit-
I'm on windows 10, evga gtx 980, 358.91 driver
 
It doesn't seem like the framerate target is working either. I set it to 58 and in-game framerate is showing 60 according to fraps.

I can confirm that osd isn't working in the witcher 3 either.
 
Fallout 4, The Witcher 3, no OSD.