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I'll add Horizon and Expeditions: Conquistador to the list. It's more then just the OSD working or not, it crashes those games as soon as or sometimes within 20 seconds of loading into the game worlds.
EDIT: Back happening again and it is related to the OSD.
Also this may not be the right place for this or it may have been mentioned someplace else but Precision OSD has a problem problem with Youtube and Twitch when using Firefox (<35.0.1). I can watch one video windowed or full screen with PrecisionX 16 OSD setup to run but upon trying to run the next video, the video plays but the screen either shows black or grey. I can either restart Firefox to get one video view again or I can open task manager and end the flash player plugin processes and then just reload the Youtube or Twitch page to then view the video. This problem does not occur at all if I do not have the OSD setup to run before going to watch Youtube or Twitch.
i7 920 @ 3.2GHz
GTX 480 FTW (stock clocks and voltages) 347.09 driver
To get around the problem with EVGA Precision X with Youtube, Twitch, Netflix, or any other video site like that... Right click anywhere in the video, go to settings and disable hardware acceleration... Videos will play correctly with no noticeable difference in quality. However, I found that Precision X also affects video players like WMP and VLC. The picture will disappear or get stuck when going between windowed/fullscreen, it also makes the taskbar icons glitchy. Note that this happens WITH THE OSD DISABLED. Also disabling hardware acceleration in the players doesn't help, like for Flash on Youtube/Twitch, etc. AFAIK, there are no reliable workarounds for these overlay issues, so I'm using MSI Afterburner in the mean time.
*edit* Oh yeah... One game I had a pretty serious issue with is Mass Effect 3... When running in borderless window mode and EVGA Precision X is running (even with OSD turned off), the whole game (when actual gameplay starts) freezes after a few seconds. Running in fullscreen mode, there is no freeze though. Without EVGA Precision X, there are no problems in borderless window mode. Also running EVGA Precision X causes Origin's in-game overlay to not work.
5.3.7 version btw.