4way is best,except 780ti
I'd suggest titan to set up a 4way-SLI , especially on 4k or surround
though you have very high scores , but in game we do need stability and more v-rams , the score in 3dmark is nothing , soon you'll forget it
I think 2way 780ti on 1080p or 3way 780ti in 1440p is smarter , 4way 780ti in multi-displays is probably a wrong way
hope you test some games with high visual effect settings
msaa will bring a much clear picture , not like the dim screen from smaa/txaa , so please use 2msaa (or noaa if acceptable) , and tell us the v-ram loss
that's why in 4way-SLI we must use the double v-ram (150% BF4 texture-mappings are brilliant , but video rams drop too fast)
and when on 8msaa (and other hi-pressure options such as god rays and hbao+) , the cards will have to be in stressful conditions , the ROPs max-out and you will see the real side of both graphics and cards : glorious picture , stable card . or failed .
you should buy a next-gen new flagship for the surrounding screens . 780ti is not matching the resolution you're using , it's fast but not balance.