I tried the beta drivers, and tinkered with the Power Management settings within Windows, but no luck so far.  I even tried my 580 with a configured .inf on the R300 driver, but the system resumed from S3 fine. 
 
Is it safe to say that what we all have in common is an EVGA X58 chipset, Windows 7 64 bit SP1, and a GTX 680? Have we all tried removing any other PCI/PCIE devices from the system (boot permitting)?  Have we tried setting our BIOS to stock? 
 
I'm continuing testing with Matt H at EVGA...

Removed Post, didn't see there was already a 2nd Page.

I recently upgraded from a Sapphire HD6950 2GB to a GTX 680.
 
I have no idea on the difference between S1 or S3 sleep mode, however my issue sounds extremely similar to what you are all experiencing.
 
I noticed that some of you went so far as to even try swapping your Intel CPU's to other Intel CPU's to see if that was an issue... no, it is not.
 
My system:
Windows 7 Ultimate 64-bit
AMD Phenom II X6 1100T BE ~ 3.4Ghz (OCed to 4Ghz)
MSI 790FX MB
8GB G. Skill 1600Mhz memory
1x WD 120GB SSD
2x (forgot brand) 2GB 5400 RPM "green" drives
42" Panasonic Viera S2 Plasma via HDMI
 
So here is what I have experienced so far:
 If I start my PC, it will NEVER load into Windows... or rather I get a black screen once the Windows logo goes away, and my TV/monitor says that there is no signal detected. If I force restart the PC, then it will always goes right into Windows with no problems. One day I noticed that I heard the start-up tone along with the standard message sounds I hear when Windows starts, so it clearly DID boot into Windows. Unplugging the HDMI cable and putting it back in after a few seconds activates the display and everything looks normal again (no error messages about failed drivers or anything).
 
Now, if the PC goes into sleep mode OR I turn-off the TV, when I come back and try to wake it OR simply turn the TV back on, it will just stay at a black screen due to no signal detected.
 
Here is where it gets interesting: If I unplug the HDMI cable, give it maybe 3-4 seconds, and then plug the cable back in (does not matter if unplugged from TV or card end), viola!... I get a picture again. It is like this 100% of the time, and it seems to be linked with the display port deactivating if the power on the display is turned-off (such as during sleep mode). It then only comes back once the device is physically unplugged and plugged back in... at least that's my theory.
 
Also, yes, I did a clean install and I made sure to use Driver Sweeper to completely remove any trace of ATi drivers before installing the GTX 680 and the latest driver available from the NVIDIA support site.
 
Some of you other people experiencing this problem, can you try what I stated above with your displays to see if it's a universal thing affecting all of us? That could help lead to a solution faster than guessing at which of the many other components may be causing this in our systems.

I would not change DVI ports, and I would not turn-off the monitor while doing it, but simply unplugging the DVI cable with the monitor on, waiting maybe 5 seconds, then plugging it back into the port you had it plugged into originally.
 
I have not yet tried disabling sleep mode, however the point to take away is that I highly doubt that there is anything physically wrong with any of our cards. My theory is that this a Windows 7/NVIDIA driver power management conflict that is yet to be resolved. I will also try using a different HDMI port on the TV to see if that makes any difference (at least to eliminate the possibility of a bad HDMI hook-up on the TV), and possibly testing the DVI port to see there is any difference (I suspect not, but worth a try at this point).
 
I'm still curious to hear back from some HDMI users to see if they can re-create what I am experiencing.
 
Also just for the record, I did have some driver errors on some java-heavy sites at one point, however that seems to have been taken-care-of... possibly by an automatic Windows or Java update I did not notice. They usually happend only once in random instances, however graphic-heavy games have so far run for hours without any performance issues, with the exception of a new game crash bug when playing World of Tanks, however I suspect that has more to do with the game than the graphics driver (I occassionally had this happen with my HD6950 also).
 
Alright, I guess the hunt for answers continues!

Dunno about the others inthis thread but I'd appreciate some Official News concerning our S3/GTX680 problem and what is beeing done about it.
 
I can't believe we're beeing asked to make Hardware and BIOS changes in order to test things out if a company like EVGA has their own Hardware Lab filed under the roof with the very same Hardware/Software we already provided.
 
Is it really that hard to keep a bothered customer informed? It's been almost a week by now since a Mod has taken a look into this Thread *sigh*

Update:
 
We are looking into this, in the meantime are there any other applications (other than precision) that may be running in the background?

Thanks for the response jacob, i didn't install any applications like precision, i only installed the included drivers alone.

I just stumbled upon this thread, and I think everyone is looking in the wrong area... Most of you list SSD's in your profile, and report issues resuming from S3 standby or having latent drive detection upon bootup.
 
I've bee investigating the Sandforce SF-2281 issues that I've been running into even on a fresh install of windows 7 and the consumer preview of windows 8.
 
So far I've come up with a few things worth trying.
Update your motherboard's firmware
Update your SSD's firmware
Get the latest intel RST drivers (if you have an intel)
Replace your SATA cable (especially if you have boot-time detection issues where detection hangs or a drive doesnt show up on occasion)

Thanks for the ideas fieldcar, but the problems arose when adding the 680. In my specific case, I was able to put my 570 back in with the 301.10 drivers and it would properly resume from sleep.  So it may be that SSDs are another piece of the puzzle.  I'll check ssd firmware and rst drivers next time I have a chance.
 
@Glythen, everyone isn't having the problem, but a few of us are.  It appears many of us have evga x58 mobos so you may be affected.

Thanks for the ideas fieldcar, but the problems arose when adding the 680. In my specific case, I was able to put my 570 back in with the 301.10 drivers and it would properly resume from sleep.  So it may be that SSDs are another piece of the puzzle.  I'll check ssd firmware and rst drivers next time I have a chance. 

 
There is nothing more frustrating than building your dream pc only to find something minor like this ruin all the fun.
I wish you the best of luck fixing your rig.
 
I've also heard suggestions that bumping up the voltage on the RAM and PCI express can remedy the S3 sleep issue, but I really doubt it will help... worth a shot maybe.

EVGA_JacobF

This issue is brig worked on, sorry I don't have any other news to report yet...

Always appreciate knowing it's still being looked in to.  Thanks.

Another week has passed without any official Information?

Another EVGA x58 mobo/GTX 680 combo.  I wonder if anyone with that combo is able to use S3?
 
BTW, I did verify my driver and SSD firmware currency as discussed back on post 47.  I did not mess with PCIE voltages yet.
 
I have also repeated the problem with three different 680s (two vanilla, one SC+) as single cards and in SLI.
 
Edit:
 
I pulled up the PDF I had made of this thread: Rule of thumb for IOH/ICH voltages??
And set IOH to 1.2 And ICH to 1.15.  That still resulted in failure so I tried IOH of 1.3 but that also did not work.

Any update on this?

[HazMatt]
Is it safe to say that what we all have in common is an EVGA X58 chipset, Windows 7 64 bit SP1, and a GTX 680? Have we all tried removing any other PCI/PCIE devices from the system (boot permitting)?  Have we tried setting our BIOS to stock? 

Just registered to say that I'm having the same issue, but on an older EVGA 790i SLI FTW with a Q9650. I am running Win7 64 SP1 though. No other PCI/PCIE cards in the system and I've tried stock BIOS settings. From what I've been reading it sounds like there are 2 unique presentations of the issue: a complete automatic reboot, and being stuck with a black screen after the system seems like it resumes (which is what I'm getting). I should probably also mention that I'm using the DisplayPort only, nothing plugged into HDMI or either DVI at the moment.
 
I'm going to have the opportunity to try the card in another computer tomorrow, so I'll let you know what happens. If it's able to resume from sleep on a different system that would definitely help with concerns about there actually being defective cards out there.
 
Thanks for looking into this. Hopefully it's some sort of driver issue that nVidia can sort out.