Monitoring software and/or an unstable system to begin with could be the culprits. You run any stability tests like LinX recently?
I no longer keep Precision running when playing, I only apply the fan speed at startup and that's it. I do monitoring through a desktop gadget now (one that doesn't use Rivatuner) and experience no lag/micro-stutter/crashes.
Try doing without Precision for now. Just play without precision running and without OSDs on for both your screen and your G15 Keyboard. If you set your settings to apply at startup, you do not need to launch precision at startup for those settings to be applied.
If that doesn't solve it, do a full stability test roundup on everything in your system. Even on stock, some components (from what I can tell, it seems like the memory or the FSB could be the issues) could fail to act properly.
Drivers could also be an issue. Going from a 9800GTX to a 480 will require a full driver sweeper of your old drivers. But, since driver sweeper doesn't work on 25x.xx drivers, the only way to go is a clean install then installing the latest driver if you're willing to go that far.
If all else fails, it could be the card. Ryan Shrout of PC Perspective found that out doing a Far Cry 2 benchmark on a 480. He had similar symptoms to what you described play out in this video:
http://www.vimeo.com/10384961