Add me to the list.  The board now randomly disconnects the USB mouse.   It's not software.  The archive from the new install does exactly the same thing.  
 
EVGA RMA'ed the board.  The replacement has the same problem, just more frequently.  The system has the keyboard and a microsoft USB wheel mouse with the lastest drivers.  The windows add/remove hardware sound prompts often.  The light in the base of the optical mouse goes out and stays out until it's unplugged and replugged.  It doesn't much matter which port it's plugged into.  With a mouse plugged into  two ports, two mice fail at random.

 

1. Please describe the issue, USB not responding? USB slow? USB stops responding
2. Which USB devices and/or ports are failing? all ports and every every device i won stops working. usb flash, kb/mouse receiver. heck i got crazy one night and even tried USB internet.
3. Which motherboard and BIOS revision are you using? e758 bios 77 i think. my original board i used pretty much every bios when it was released and  the problem still occured.
4. Did this problem occur right away or over time? If so how long did it take before the problem showed? Does this issue occur on every system boot? over time the problem started happening. it acts like its degrading over time. get worse and more frequent.
5. Does this issue occur outside of the Operating System? Such as in BIOS? If not, which Operating System is being used? yes it happens outside the OS. in bios nothing will work unless i shutdown the PSU and let it sit unpowered for 5 minutes than it will work again, for awhile.
6. Has the motherboard been RMA'd by EVGA? If so did the issue go away or persist?  This is happening on my original board and the RMA replacement i have received in the last month that is being RMA'd for sound problems..  one board after another is broken.

 
What i notice is that the problem persists across amny different types of boards. there is pretty much one common denominator.  I wont name names becasue the fanboy's will come running.
 
Is it an issue with the chipset? is it a board manufacturing problem?

Upon further investigation into randomness of my USB drop outs.  I have found there could be (most likely is) another problem lurking here that goes unnoticed.  And, has absolutely nothing to do with USB drop outs.
 
I read on Logitech forums that the G19 (and most likely all of the G-series keyboards), are sensitive to ESD or EMI emissions from GSM phones. 
 
Please read CharlesB's post: http://forums.logitech.com/t5/G-Series-Gaming-Keyboards/G19-goes-off-reboots-often/td-p/359586/page/6
 
As fate would have it, I was reading through what CharlesB posted and at that moment my phone received a email.  My keyboard just shut down and rebooted.  I have since moved my phone away from the keyboard and it has yet to drop out. 
 
If your experiencing similar random drop outs.  Try moving your phone away from the your keyboard.
 
I will of course monitor this, and post back if it drops out again without the phone in close proximity.

spoke too soon ,   i got 1 reboot the nothing again.   i now have 0 USB slots working.
stumped.

i just bought a nice logic tech g510 for 90.00 it is now on my 350.00 emachine and my 19.99 ten year old keyboard is on my 3500.00 rig .  both are working like champs now. i guess thats how i must roll.  i can work on OCing while this usb thingy gets worked out.   

Still having this issue. About 1 out of 10 times I plug in my iphone to sync/charge at night I will suddenly lose all my USB devices. Keyboard and mouse lights flicker for a sec then go dim.....
 
Only way to fix is hard reboot....

I have a x58 SLI original board.

Please describe the issue, USB not responding? USB slow?
 
On boot Logitech G15 keyboard (also happens with the G510) keys will not work. Cannot get into BIOS. Also will not correctly wake up from S3 sleep. It the PC powers on, powers off and boots normally rather then wake from S3. Additionally after I installed new nVidia Geforce drivers, on reboot the keyboard would not work during login screen. Normally the keyboard only does not work during BIOS and post, and OS (F8) menu selection.

Which USB devices and/or ports are failing?
 
Any USB port the keyboard is plugged into seems to behave this way.

Which motherboard and BIOS revision are you using?
 
x58 SLI BIOS E75883

Did this problem occur right away or over time? If so how long did it take before the problem showed? Does this issue occur on every system boot?
 
I believe the Logitech Keyboard worked correctly under a different older version of the BIOS. I only recently (Feb. 2012) have upgraded to the E75883 release.

Does this issue occur outside of the Operating System? Such as in BIOS? If not, which Operating System is being used?
 
Occurs during POST, and recently occurred in Windows 7 login screen, where num lock would work. But other keys, such as ctrl-alt-del would not. Unplugging keyboard and moving to another port did not seem to cause USB re-detection to occur.[
 
No, the motherboard has not been RMA'ed.   

Please describe the issue, USB not responding? USB slow?

--not slow..just not detect usb 3.0 hdd when it's fail.

Which USB devices and/or ports are failing?

--external usb 3.0

Which motherboard and BIOS revision are you using?

x58 sli3 with 83

Did this problem occur right away or over time? If so how long did it take before the problem showed? Does this issue occur on every system boot?

it's over time and every system boot.

Does this issue occur outside of the Operating System? Such as in BIOS? If not, which Operating System is being used?

sometimes not detect usb keyboard when it's booting

Has the motherboard been RMA'd by EVGA? If so did the issue go away or persist?

haven't rma yet.

I came to this thread because I was having odd USB problems with my X58 SLI, but after some process of elimination, I determined it was caused by the Acronis Nonstop Backup service.  I set it to disabled (I don't use the non-stop backup feature) in services.
 
My problem was that whenever I would plug in a thumb drive, it would take about 30 seconds for it to appear in Windows Explorer, and disk errors would be logged in the event logs.
 
I consider myself lucky now!  I've not had the dying USB ports problem.

EVGA_JacobF

Hi all,

We are still trying to reproduce the USB issue that some are experiencing in the forum. In order to correct this potential issue we need detailed information on the following items. Please respond in this thread with the following information. Please only post once in this thread.

1. Please describe the issue, USB not responding? USB slow?
2. Which USB devices and/or ports are failing?
3. Which motherboard and BIOS revision are you using?
4. Did this problem occur right away or over time? If so how long did it take before the problem showed? Does this issue occur on every system boot?
5. Does this issue occur outside of the Operating System? Such as in BIOS? If not, which Operating System is being used?
6. Has the motherboard been RMA'd by EVGA? If so did the issue go away or persist?

Thanks,
Jacob

Thanks for your help.
** EDIT **  Please list all usb devices you have installed.

 
 
b4 i knoticed this topic....i had trouble with usb ports ever since A74 came out.
8-08-2011.   
 
had trouble with all usb ports with newer bios (A74)  for p55 ftw,,, using razer lachesis ..broken 2 mice for this reason lol .. so i download all the bios n tested which one got rid of my isse and a51 been helping .. so far no lagging or slow downs with my mouse....  mayb you shouldnt touch the bio n get new programer who can write the bios .. just idea lol
 

i went back to this bios so far stuff works  
 
A51 Updates:
 
* Improves USB Compatibility
* New CPU Support
* Improves Memory Compatibility
* ClockGen Switch Mode Disable Option to not power up twice
 
A70 works great too.. 
 

ever since i totally got rid of a74 bios everything seems to fuction better for me now ... as weird this going to sound,,,  but when A74 bios was install on 3 on bios sel. all my other bios where affect by a74 bios they got same usb issues... i got rid of A74 switch to A51 everything works again no usb issues. mayb just me i dont know lol
7/15/12
" SCRATCH A70 STARTED ACTING UP THIS MORNING WITH USB PORTS LOL.. PIECE OF **** MOBO I THINK". IF THIS TOPIC WAS POSTED IN 2010 **** UP WITH A FIX OR A REFUND FOR ****TY MOBO LOL .WENT BACK TO A51 TO SEE IF THAT ACTS UP ...THOUGHT BIOS UPDATE FIX ISSUES NOT MAKE NEWER ONES LOL 
  
 
GEEEZ NO FIX YET **** GOING ON

Not too long after boot, though not immediately, I get an error from Windows this USB port has stopped working (Code 43).

1. Which USB devices and/or ports are failing? Port 5, Hub 1
2. Which motherboard and BIOS revision are you using? 680SLI Mb & NF68_P33 BIOS
3. Did this problem occur right away or over time? If so how long did it take before the problem showed? Does this issue occur on every system boot? Just showed up out of the blue after having the PC built up for 3+ years.
4. Does this issue occur outside of the Operating System? Such as in BIOS? If not, which Operating System is being used? I can't tell. OS= Win7 64bit
5. Has the motherboard been RMA'd by EVGA? No

What exactly is failing? Is it a hardware failure on the USB support on the motherboard? Only one port is failing, all others are still working. How do I fix this?

This thread actually ended back in 2012 and someone decided to reopen it. I will lock it and ask that if you have a USB problem please start a new thread