I just got a new card and was excited to set it up. To my dismay it never did start working properly. The fans turned on and the led but nothing else. I was beginning to think it was a bad card, that is until I tried out an older card and tried putting it into the slot. To my surprise that didn't work either. I had all the proper power cables connected, and the card firmly in place, but the bios just won't recognize it's there, with either card and the computer doesn't recognize it's there and neither is the program that I downloaded with the card.
My build for what it's worth
z87stinger
4650k i5
8g skill ram 1333 ddr3
r9 280 dual x Saphhire GPU
Cooler master 550w PSU