I was looking into this as well, but looking at pics from this thread , it looks like it would either sit on top of the power supply and block air flow, or just not fit in at all. It looks really low. Im thinking of upgrading my 480 to a 780 Ti, and need to decide reference cooler or waterblock. Right now I have a waterblock on the 480 and it runs ok, but I think the 780 would generate more heat and the evga kit might not be good enough to cool everything.

d wray, the 780 Ti will be fine in there.  Despite the fact that it's MANY times faster than you GTX 480, it's a second generation Kepler chip and runs a LOT cooler in general than a first gen Fermi (your 480).  The 480 is notorious for being one of Nvidia's hottest running chips in recent years, if your Hadron Hydro cooling is keeping it in check, it will most definitely keep the 780 Ti tamed.  I'm currently running an R9 290X on liquid in mine and the temps are fantastic.  The 290X is a much hotter running chip than the 780 Ti, so you'll be fine, trust me.  The EVGA liquid kit is actually pretty capable (minus the pump/reservoir, I had some leaking issues with mine but that's another story).